The Pathogen Predators Program of DARPA would represent a significant departure from conventional antibacterial therapies that rely on small molecule antibiotics. While antibiotics have been remarkably effective in the past, their widespread use has led to the emergence of antibiotic-resistant bacterial infections that are difficult or impossible to treat. In vitro studies have shown that predators such as Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus can prey upon more than one hundred different human pathogens and will also prey on multi-drug resistant bacteria.
The Pathogen Predators program will answer three fundamental questions about bacterial predators:
1) Are predators toxic to recipient (host) organisms?
2) Against what pathogens (prey) are predators effective?
3) Can pathogens develop resistance to predation?
This list [of bacteria that could be killed by predator bacteria] includes NIAID (National Institute of Allergy and Infectious Diseases) Category A and B threats to national security:
NIAID Category A and B
Yersinia pestis (i.e. plague)
Francisella tularensis (i.e. tularemia)
Coxiella burnetii (i.e. Q fever)
Rickettsia prowazekii (i.e. typhus)
Burkholderia mallei (i.e. glanders)
Burkholderia pseudomallei (i.e. melioidosis)
Source DARRA (pdf)